⮝ Full datasets listing
PXD062496
PXD062496 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Novel Peptidomic Analysis Identifies Peptide Clusters with Potential for Disease Diagnosis and Dysregulated Proteolytic Processing |
| Description | Mass spectrometry-based peptidomics provides a comprehensive approach to delineate the global proteolytic landscape of diseases and to identify potential biomarkers. However, current data analysis methods struggle to distill the peptidomic signatures of diseases. In this study, we conducted a peptidomic analysis of plasma from individuals with β-thalassemia. By applying the amino acid score method and its tailored data visualization techniques, a clear profile of protein degradation emerged from the redundant data. Notably, the introduction of heavy labeled peptides or reference samples in targeted quantitative peptidomics led to the first proposal of peptide cluster-based potential diagnostic biomarkers of β-thalassemia. In conjunction with proteomics, the disease characteristics of molecular networks composed of peptides, proteases, and proteins were revealed, highlighting the importance of integrating peptidomics and proteomics technologies. |
| HostingRepository | iProX |
| AnnounceDate | 2025-04-02 |
| AnnouncementXML | Submission_2025-11-24_23:23:58.909.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Na Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | oxidation |
| Instrument | Orbitrap Exploris 480; Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-04-01 21:04:49 | ID requested | |
| ⏵ 1 | 2025-11-24 23:23:59 | announced |
Publication List
| Li N, Zhu Y, Yan Y, Wang J, Niu L, Ding X, Zhang M, Xie Z, Cai T, Guo X, Luo J, An P, Guo X, Yang F, Single-Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics. Adv Sci (Weinh), 13(5):e10910(2026) [pubmed] |
Keyword List
| submitter keyword: peptidomics, β-thalassemia, biomarker |
Contact List
| Fuquan Yang | |
|---|---|
| contact affiliation | Institute of Biophysics, Chinese Academy of Sciences |
| contact email | fqyang@ibp.ac.cn |
| lab head | |
| Na Li | |
| contact affiliation | Institute of Biophysics, Chinese Academy of Sciences |
| contact email | lina@ibp.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
