PXD062420 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Definition of the human mitochondrial TOM interactome reveals TRABD as new interacting protein (MAPL IP data) |
Description | The mitochondrial proteome arises from dual genetic origin. Nuclear-encoded proteins need to be transported across or inserted into two distinguished membranes, and the TOM complex represents the main translocase in the outer mitochondrial membrane. Its composition and regulations have been extensively investigated within yeast cells. However, we have little knowledge of the TOM complex composition within human cells. Here, we have defined the TOM interactome in a comprehensive manner using biochemical approaches to isolate the TOM complex in combination with quantitative mass spectrometry analyses. Within these studies, we defined the pleiotropic nature of the human TOM complex, including new interactors, such as TRABD. Our studies provide a framework to understand the various biogenesis pathways that merge at the TOM complex within human cells. |
HostingRepository | PRIDE |
AnnounceDate | 2025-04-15 |
AnnouncementXML | Submission_2025-04-15_01:05:11.421.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Julian Bender |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2025-03-31 09:59:58 | ID requested | |
⏵ 1 | 2025-04-15 01:05:11 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: translocase of the outer mitochondrial membrane, AP-MS,mitochondria, protein import, quantitative mass spectrometry, HEK293T cells |
Contact List
Bettina Warscheid |
contact affiliation | Chair of Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, Würzburg, Germany |
contact email | bettina.warscheid@uni-wuerzburg.de |
lab head | |
Julian Bender |
contact affiliation | University of Wuerzburg
Chair of Biochemistry II
Am Hubland
97074 Würzburg |
contact email | julian.bender@uni-wuerzburg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062420
- Label: PRIDE project
- Name: Definition of the human mitochondrial TOM interactome reveals TRABD as new interacting protein (MAPL IP data)