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PXD062420

PXD062420 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDefinition of the human mitochondrial TOM interactome reveals TRABD as new interacting protein (MAPL IP data)
DescriptionThe mitochondrial proteome arises from dual genetic origin. Nuclear-encoded proteins need to be transported across or inserted into two distinguished membranes, and the TOM complex represents the main translocase in the outer mitochondrial membrane. Its composition and regulations have been extensively investigated within yeast cells. However, we have little knowledge of the TOM complex composition within human cells. Here, we have defined the TOM interactome in a comprehensive manner using biochemical approaches to isolate the TOM complex in combination with quantitative mass spectrometry analyses. Within these studies, we defined the pleiotropic nature of the human TOM complex, including new interactors, such as TRABD. Our studies provide a framework to understand the various biogenesis pathways that merge at the TOM complex within human cells.
HostingRepositoryPRIDE
AnnounceDate2025-04-15
AnnouncementXMLSubmission_2025-04-15_01:05:11.421.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJulian Bender
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-03-31 09:59:58ID requested
12025-04-15 01:05:11announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: translocase of the outer mitochondrial membrane, AP-MS,mitochondria, protein import, quantitative mass spectrometry, HEK293T cells
Contact List
Bettina Warscheid
contact affiliationChair of Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, Würzburg, Germany
contact emailbettina.warscheid@uni-wuerzburg.de
lab head
Julian Bender
contact affiliationUniversity of Wuerzburg Chair of Biochemistry II Am Hubland 97074 Würzburg
contact emailjulian.bender@uni-wuerzburg.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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