PXD062412
PXD062412 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Toward a Comprehensive Map of Rab-Mediated Cargo Transport to Migrasomes |
| Description | Migrasomes are essential intermediates for intercellular communication, involved in critical processes such as embryonic development, angiogenesis, and blood coagulation. So far, a comprehensive understanding of the protein cargoes within migrasomes and their transport mechanisms, which is fundamental to advancing the understanding of migrasomes function, is still lacking. In this study, we investigated the Rab-mediated cargo transport network to migrasomes. Rabs selectively transported proteins to migrasomes that are enriched in intracellular vesicle trafficking pathways. By integrating migrasomes protein profiling and Rab-effectors under various Rab activations, we identified key driving proteins involved in Rab-mediated cargo delivery to migrasomes. Additionally, we uncovered and validated that Rabs transported plasma membrane-localized receptors and matrix metalloproteinase to migrasomes, providing new insights into their in vivo functions. The proteomic dataset and integrated approach can be applied in further investigation of migrasomes in both physiological and disease contexts. |
| HostingRepository | iProX |
| AnnounceDate | 2025-03-31 |
| AnnouncementXML | Submission_2025-03-31_05:17:32.309.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Haohao Tang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-03-31 05:16:50 | ID requested | |
| ⏵ 1 | 2025-03-31 05:17:32 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Rab-Mediated Cargo Transport, Migrasomes |
Contact List
| Yang Chen | |
|---|---|
| contact affiliation | Peking University Health Science Center |
| contact email | chenyang1816185048@bjmu.edu.cn |
| lab head | |
| Haohao Tang | |
| contact affiliation | Peking University Health Science Center |
| contact email | Tanghaohao0987@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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