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PXD062361

PXD062361 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA Metal-Dependant Formate Dehydrogenase Advances the Formate Bio-economy
DescriptionIn this manuscript a multi-subunit metal dependent FDH is functionally expressed in a strain of E. coli engineered to assimilate all energy and biomass from formate. The replacement of the previously described FDH with this new, faster FDH allows for improved growth parameters rivaling natural formatotrophs for the first time. This new, robsulty growing formatotrophic E. coli was engineered to produce mevalonate and achieved the highest reported titer for any bioproduct from formate in fed batch mode. Finally the authors explored bioproducion from electrochemically-derived and lignin-derived formate, demonstrating the first example of a bioproduct produced using liginin-derived formate as a feedstock.
HostingRepositoryPRIDE
AnnounceDate2025-06-06
AnnouncementXMLSubmission_2025-06-06_14:45:03.743.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChristopher Petzold
SpeciesList scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationListmonohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-03-28 13:50:44ID requested
12025-06-06 14:45:04announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: isoprenol, mevalonate,Bakar Bioenginuity,Formate dehydrogenase, formate, reductive glycine pathway, bioproducion
Contact List
Christopher J. Petzold
contact affiliationStaff Scientist Biological Systems & Engineering Division Lawrence Berkeley National Laboratory Berkeley CA 94720
contact emailcjpetzold@lbl.gov
lab head
Christopher Petzold
contact affiliationLawrence Berkeley National Laboratory
contact emailcjpetzold@lbl.gov
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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