PXD062337
PXD062337 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Engineered bacteria in photothermal hydrogel (EBPH) for metabolic regulating |
| Description | We reported the living therapeutic system constructed by the engineered bacteria in photothermal hydrogel (EBPH) for metabolic regulating enhanced tumor immunotherapy (Fig 1). The Escherichia coli strain BL21(DE3) cells were employed and engineered to express lactate oxidase (LOX) and glucose oxidase (GOX) under the control of thermosensitive promoter. The rewired cells were encapsulated into the photothermal hydrogel formed by constructed with sodium alginate (SA) and polypyrrole (PPy). After injection the EBPH around the tumor, the in-situ expression of LOX and GOX was induced by the NIR-II laser irradiation at 1064 nm to catalyze the degradation of glucose and lactate. EBPH could regulate the energy metabolism of tumor cells and relieve the immunosuppressive TME. Meanwhile, EBPH stimulated a series of antitumor immunological responses including the effect of immunogenic cell death (ICD), the activation of cyclic guanosine monophosphate adenosine monophosphate synthase/interferon gene stimulator (cGAS/STING) pathway, the stimulation of T cells, the polarization of macrophages to M1 phenotype and the generation of memory T cells for long term tumor suppression. Our work establishes an approach of living therapeutic hydrogel for metabolic regulating enhanced tumor immunotherapy. |
| HostingRepository | iProX |
| AnnounceDate | 2025-03-28 |
| AnnouncementXML | Submission_2025-03-28_00:39:44.648.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Baizhu Chen |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-03-28 00:39:31 | ID requested | |
| ⏵ 1 | 2025-03-28 00:39:45 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: photothermal hydrogel (EBPH), metabolic regulating |
Contact List
| Baizhu Chen | |
|---|---|
| contact affiliation | Sun Yat-sen University |
| contact email | chenbzh8@mail.sysu.edu.cn |
| lab head | |
| Baizhu Chen | |
| contact affiliation | Sun Yat-sen University |
| contact email | chenbzh8@mail.sysu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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