PXD062319

PXD062319 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Integrative Analysis of Saliva-Derived Exosomal Proteome and Lipidome for the Diagnosis of Esophageal Squamous Cell Carcinoma
Description	Early diagnosis of esophageal squamous cell carcinoma (ESCC) is crucial for improving patient prognosis. Currently, the diagnosis of ESCC primarily relies on endoscopic biopsy. Salivary exosomes have shown great potential in non-invasive screening, but their proteomic and lipidomic characteristics remain to be reported. Exosomes were isolated from salivary samples of 54 patients with ESCC and 62 healthy controls using ultracentrifugation, and subsequently subjected to non-targeted proteomic and lipidomic analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Differentially expressed proteins and lipids in salivary exosomes were identified through differential analysis, and a comprehensive analysis of multi-omics data was performed using correlation analysis.
HostingRepository	PRIDE
AnnounceDate	2025-08-25
AnnouncementXML	Submission_2025-08-24_17:32:16.783.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Zhong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-27 10:25:51	ID requested
⏵ 1	2025-08-24 17:32:17	announced

Publication List

Zhong W, Liu J, Xie J, Zhang Z, Gong Z, Yan Z, Cao Q, Integrative analysis of saliva-derived exosomal proteome and lipidome for the diagnosis of esophageal squamous cell carcinoma. BMC Cancer, 25(1):1254(2025) [pubmed]
10.1186/s12885-025-14452-x;

Zhong W, Liu J, Xie J, Zhang Z, Gong Z, Yan Z, Cao Q, Integrative analysis of saliva-derived exosomal proteome and lipidome for the diagnosis of esophageal squamous cell carcinoma. BMC Cancer, 25(1):1254(2025) [pubmed]

10.1186/s12885-025-14452-x;

Keyword List

submitter keyword: esophageal squamous cell carcinoma, exosomes, proteomics, lipidomics, diagnosis

submitter keyword: esophageal squamous cell carcinoma, exosomes, proteomics, lipidomics, diagnosis

Contact List

Wei Zhong
contact affiliation	Department of Thoracic Surgery and Lung Transplantation, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China
contact email	zhongwei2@sdslyy.wecom.work
lab head
Wei Zhong
contact affiliation	Department of Thoracic Surgery and Lung Transplantation, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China
contact email	zhongwei2@sdslyy.wecom.work
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD062319
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD062319

PRIDE project URI

Repository Record List

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