PXD062309

PXD062309 is an original dataset announced via ProteomeXchange.

Title	Combining information on degradomics and gene expression data in prospecting metastatic melanoma proteolytic signatures
Description	Melanoma is an aggressive skin cancer with a high metastatic potential, influenced by both genetic and environmental factors. Proteases play a key role in shaping the tumor microenvironment and enabling transformed cells to actively colonize distant sites (metastasis). We performed proteomic mapping of protease cleavage sites in formalin-fixed paraffin-embedded tissue samples and profiled potentially active proteases in samples from melanoma patients with distinct prognostic outcomes. Although protein abundance alone did not indicate potential markers of disease progression, the observed cleaved fragments may serve for monitoring potentially active proteases in patient samples in targeted proteomics analysis. The findings provide valuable insights into melanoma biology and potential therapeutic prospects.
HostingRepository	PRIDE
AnnounceDate	2026-01-02
AnnouncementXML	Submission_2026-01-02_05:04:52.065.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andre Zelanis
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-27 06:27:30	ID requested
⏵ 1	2026-01-02 05:04:52	announced

10.1016/J.JPROT.2025.105597;

submitter keyword: proteolytic signaling,melanoma, proteolysis, Formalin-Fixed Paraffin-Embedded.

Andre Zelanis
contact affiliation	Lan head / Functional Proteomics Laboratory / Federal University of Sao Paulo / Sao Jose dos Campos, Sao Paulo, Brazil
contact email	andre.zelanis@unifesp.br
lab head
Andre Zelanis
contact affiliation	Laboratory of Functional Proteomics - Department of Science and Technology - Federal University of São Paulo (UNIFESP), Sao Jose dos Campos-SP, Brazil
contact email	zelanis@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD062309

PRIDE project URI

• PRIDE
  1. PXD062309
     1. Label: PRIDE project
     2. Name: Combining information on degradomics and gene expression data in prospecting metastatic melanoma proteolytic signatures