⮝ Full datasets listing
PXD062308
PXD062308 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Stabilization of the PP2A-B56α complex overcomes Venetoclax-Azacitidine resistance by impairing oxidative phosphorylation in AML |
| Description | Cell metabolic rewiring is associated with resistance to venetoclax-azacitidine (Ven-Aza) combination therapy and relapse in acute myeloid leukemia (AML) patients. Drug-resistant cells exhibit an enhanced reliance on oxidative phosphorylation (OXPHOS) for energy production. Therefore, impairing mitochondrial metabolism represents an exciting strategy to face this unmet clinical need. We have recently demonstrated that the specific activation of the phosphatase PP2A-B56α enhances the pro-apoptotic efficacy of venetoclax in AML. Here, through leveraging unbiased multi-omics-based approaches, and using both genetic and pharmacological tools, we define key new roles for the tumor suppressor PP2A-B56α complex in OXPHOS regulation and treatment responses in disease-relevant AML models. From a translational perspective, the specific stabilization of PP2A-B56α heterocomplex with the novel PP2A molecular glue, RPT04402, reduces OXPHOS levels in treatment-resistant AML cells and improves treatment response in both Ven-Aza-sensitive and -resistant AML cell lines, primary cells, and in vivo models. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-10-27 |
| AnnouncementXML | Submission_2026-09-04_03:27:57.479.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Joaquin Fernandez-Irigoyen |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; N6-acetyl-L-lysine; 2-pyrrolidone-5-carboxylic acid (Gln); L-methionine sulfoxide |
| Instrument | instrument |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-03-27 06:00:40 | ID requested | |
| ⏵ 1 | 2026-09-04 03:27:57 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: AML, resistance, OXPHOS |
Contact List
| Goutham Narla | |
|---|---|
| lab head | |
| Joaquin Fernandez-Irigoyen | |
| contact affiliation | Navarrabiomed |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003729/ |
