PXD062291
PXD062291 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Catalytic mechanism of an Actin-dependent adenylyltransferase involved in ubiquitin signaling |
Description | The two effectors LnaB and MavL of Legionella pneumophila coordinate the conversion of phosphoribosyl ubiquitin (PR-Ub) released by reversal of ubiquitination induced by members of the SidE effector family into functional Ub. LnaB acts as an actin-dependent phosphoryl AMPylase that converts PR-Ub into ADP-ribosylated (ADPR)-Ub. Catalysis by LnaB requires the novel conserved S-HxxxE motif present in a large family of bacterial toxins. Here we uncovered a novel adenylylation mechanism involved in two-step ATP hydrolysis. |
HostingRepository | iProX |
AnnounceDate | 2025-03-27 |
AnnouncementXML | Submission_2025-03-26_23:37:57.534.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jiaqi Fu |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 240 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-03-26 23:35:46 | ID requested | |
⏵ 1 | 2025-03-26 23:37:57 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Protein AMPylation |
Contact List
Jiaqi Fu | |
---|---|
contact affiliation | The First Hospital of Jilin University |
contact email | fujiaqi@jlu.edu.cn |
lab head | |
Jiaqi Fu | |
contact affiliation | The First Hospital of Jilin University |
contact email | fujiaqi@jlu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |