PXD062277

PXD062277 is an original dataset announced via ProteomeXchange.

Title	Co-immunoprecipitation and proteomic analysis of Major Histocompatibility Complex Class I-related (MR1) mutants
Description	Identification of cellular proteins mediating presentation of bacterial antigens by the MHC I-related protein MR1. MR1 mutant proteins that differ in their capacity to present antigens from different sources were immunoprecipitated and their interacting proteins were compared to identify candidate proteins involved in the different antigen presentation pathways.
HostingRepository	PRIDE
AnnounceDate	2026-04-06
AnnouncementXML	Submission_2026-04-05_18:47:50.710.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luisa Nieto Ramirez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue
Instrument	timsTOF fleX

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-26 19:24:04	ID requested
⏵ 1	2026-04-05 18:47:51	announced

10.1016/j.jbc.2026.111317;

Kulicke CA, Lemon C, Krawic JR, Nieto Ramirez LM, Kim SJ, Narayanan G, Tafesse FG, Hildebrand WH, Dobos KM, Lewinsohn DM, Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens. J Biol Chem, 302(4):111317(2026) [pubmed]

submitter keyword: co-immunoprecipitation, antigen presentation,MR1, endosomal trafficking

Karen Dobos
contact affiliation	Professor, Microbiology, Immunology, and Pathology Colorado State University Co-Director, Mycobacteria Research Laboratories Scientific Director, Rocky Mountain Regional Biocontainment Laboratory
contact email	Karen.Dobos@ColoState.edu
lab head
Luisa Nieto Ramirez
contact affiliation	Colorado State University
contact email	luisam@colostate.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD062277

PRIDE project URI

• PRIDE
  1. PXD062277
     1. Label: PRIDE project
     2. Name: Co-immunoprecipitation and proteomic analysis of Major Histocompatibility Complex Class I-related (MR1) mutants