PXD062216

PXD062216 is an original dataset announced via ProteomeXchange.

Title	Unbiased Proteomic Approach Reveals Rejuvenation-Associated Effects of Quinoa Bioester on Skin
Description	We investigated the effects of a quinoa bioester in topical formulations on skin aging. Sixty-one female participants, one for each age between 20 and 80 years, with Fitzpatrick skin types IV or lower, underwent a 30-day treatment on the volar forearm. Skin samples were collected before and after treatment and subjected to proteomic analysis. Paired comparisons revealed an increased abundance of key proteins associated with skin health in the quinoa bioester-treated forearms; notable examples include desmoglein-1, desmocollin-1, and filaggrin which are linked to skin barrier function, antioxidative defense, and cellular turnover. To further assess the impact of quinoa bioester on skin aging, we developed a predictive model using Support Vector Regression based on the full proteomic profiles of the untreated forearms aiming to estimate the relative biological ages after treatments. Our model inferred the quinoa bioester-treated forearms as having a proteomic profile of a younger age compared to placebo-treated counterparts. Taken together, our results suggest that quinoa bioester contributes to skin health and offers potential for applications in anti-aging skincare treatments.
HostingRepository	PRIDE
AnnounceDate	2026-03-17
AnnouncementXML	Submission_2026-03-17_00:32:56.270.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Amanda Caroline Camillo-Andrade
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-25 08:40:21	ID requested
⏵ 1	2026-03-17 00:32:56	announced

Dataset with its publication pending

submitter keyword: quinoa bioester, proteomics, mass spectrometry, Support Vector Regression,Skin, aging

Paulo Costa Carvalho
contact affiliation	Laboratory for Structural and Computational Proteomics, Carlos Chagas Institute, Fiocruz, Paraná, Brazil
contact email	paulo@pcarvalho.com
lab head
Amanda Caroline Camillo-Andrade
contact affiliation	Fiocruz-PR
contact email	amandacamillodea@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD062216
     1. Label: PRIDE project
     2. Name: Unbiased Proteomic Approach Reveals Rejuvenation-Associated Effects of Quinoa Bioester on Skin