⮝ Full datasets listing

PXD062156

PXD062156 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative proteomics analysis of radiation-induced rectal injury in rectal cancer patients undergoing radiotherapy
DescriptionRadiotherapy constitutes a pivotal approach in the management of pelvic malignant tumors. Despite notable strides in radiation technology, the incidence of collateral damage to neighboring normal tissues remains a prominent concern. Radiation-induced rectal injury (RRI) significantly impacts the postoperative quality of life of patients undergoing pelvic radiotherapy. We gathered RRI tissues alongside non-irradiated rectal tissues for a quantitative proteomic examination employing data-independent acquisition proteomics. Our analysis unveiled differentially expressed proteins (DEPs). Gene Ontology and Kyoto Encyclopedia of Genes and Genome enrichment analyses of DEPs uncovered conventional pathway modifications such as cytokine activation and extracellular matrix alterations, alongside emerging potential biological mechanisms implicated in RRI, including neutrophil extracellular traps, macrophage-to-myofibroblast transition, and metabolic reprogramming.
HostingRepositoryiProX
AnnounceDate2025-03-23
AnnouncementXMLSubmission_2025-03-23_20:08:34.653.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHuajun Cai
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Astral
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-03-23 20:08:19ID requested
12025-03-23 20:08:35announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: radiation-induced rectal injury, quantitative proteomics
Contact List
Guoxian Guan
contact affiliationThe First Affiliated Hospital of Fujian Medical University
contact emailfjxhggx@163.com
lab head
Huajun Cai
contact affiliationThe First Affiliated Hospital of Fujian Medical University
contact emailfjmucaihj@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI