PXD062156
PXD062156 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative proteomics analysis of radiation-induced rectal injury in rectal cancer patients undergoing radiotherapy |
| Description | Radiotherapy constitutes a pivotal approach in the management of pelvic malignant tumors. Despite notable strides in radiation technology, the incidence of collateral damage to neighboring normal tissues remains a prominent concern. Radiation-induced rectal injury (RRI) significantly impacts the postoperative quality of life of patients undergoing pelvic radiotherapy. We gathered RRI tissues alongside non-irradiated rectal tissues for a quantitative proteomic examination employing data-independent acquisition proteomics. Our analysis unveiled differentially expressed proteins (DEPs). Gene Ontology and Kyoto Encyclopedia of Genes and Genome enrichment analyses of DEPs uncovered conventional pathway modifications such as cytokine activation and extracellular matrix alterations, alongside emerging potential biological mechanisms implicated in RRI, including neutrophil extracellular traps, macrophage-to-myofibroblast transition, and metabolic reprogramming. |
| HostingRepository | iProX |
| AnnounceDate | 2025-03-23 |
| AnnouncementXML | Submission_2025-03-23_20:08:34.653.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Huajun Cai |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-03-23 20:08:19 | ID requested | |
| ⏵ 1 | 2025-03-23 20:08:35 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: radiation-induced rectal injury, quantitative proteomics |
Contact List
| Guoxian Guan | |
|---|---|
| contact affiliation | The First Affiliated Hospital of Fujian Medical University |
| contact email | fjxhggx@163.com |
| lab head | |
| Huajun Cai | |
| contact affiliation | The First Affiliated Hospital of Fujian Medical University |
| contact email | fjmucaihj@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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