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PXD062153

PXD062153 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTargeting PGC-1α in Bladder Cancer: Unraveling Energy Metabolism Reprogramming for Therapeutic Intervention
DescriptionMetastatic bladder cancer is a malignant tumor with high metastatic potential. The etiology and molecular mechanism are still not fully understood. This study aimed to investigate the effect of PGC-1 α siRNA delivered by liposomal nanoparticles on bladder cancer cells, in order to reveal its mechanism in tumor cell reprogramming and energy metabolism regulation. Through transcriptome, proteome and metabolomics, we found that PGC-1 α was significantly upregulated in bladder cancer metastasis, and constructed a nanoparticle delivery system for efficient delivery of PGC-1 α siRNA. In vitro results showed that PGC-1 α silencing inhibited mitochondrial biogenesis and energy metabolism in bladder cancer cells, and interfered with the extranuclear transport of mRNA. Metabolomic analysis further confirmed the changes in cellular metabolism, especially the effects of glycolysis and tricarboxylic acid cycle pathways. The in vivo model further verified that si-pgc-1 α LNP could significantly reduce the number of lung metastases of metastatic bladder cancer, showing anti metastatic potential. These findings reveal the important role of PGC-1 α in the regulation of energy metabolism and metastasis of bladder cancer cells, and provide a new strategic direction for the treatment of metastatic bladder cancer.
HostingRepositoryiProX
AnnounceDate2025-03-22
AnnouncementXMLSubmission_2025-03-23_20:03:22.881.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterZhenghua Liu
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-03-23 20:03:08ID requested
12025-03-23 20:03:23announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Metastatic bladder cancer
Contact List
Hao Zhang
contact affiliationThe First Hospital of China Medical University
contact emailLunar8511@126.com
lab head
Zhenghua Liu
contact affiliationThe First Hospital of China Medical University
contact email1545559471@qq.com
dataset submitter
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iProX dataset URI