PXD062097
PXD062097 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Myocardial Mitochondrial Antiviral Signaling Protein Promotes Heart Ischemia-reperfusion Injury via RIG-I Signaling-proteomic sequencing |
| Description | Myocardial ischemia-reperfusion injury (MIRI) is a life-threatening complication of myocardial infarcts, with inner mitochondrial membrane protein dysfunction involved in MIRI-induced heart injury. The role of outer mitochondrial membrane protein MAVS is unknown. Here we show that MAVS expression increased in infarcted myocardium of wild-type (WT) mice. Global MAVS-knock-out (MAVS-KO) or myocardial-specific MAVS knockdown protects mice from acute and chronic MIRI, reducing apoptosis, leukocyte infiltration, etc. MIRI induces double-stranded RNA in affected myocardium, activating intracellular retinoic acid-inducible gene I (RIG-I) signaling, which led to MAVS aggregation for further non-canonical downstream signaling. MAVS aggregates recruit tumor necrosis factor associated factor family 6 (TRAF6) and transforming growth factor-β-activated kinase 1 (TAK1), activating mitogen-activated protein kinase (MAPK) pathway and apoptosis. MAVS-KO reduces -jun-NH2 terminal kinase (JNK) phosphorylation and apoptosis. JNK inhibition benefits WT mice and JNK agonist impairs protection in MAVS-KO mice. MIRI activates RIG-I/MAVS via TAK1/TRAF6-MAPK/JNK axis, suggesting new MIRI therapeutic targets to treat MIRI. |
| HostingRepository | iProX |
| AnnounceDate | 2025-03-20 |
| AnnouncementXML | Submission_2025-07-08_22:55:09.177.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhenyu Kang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-03-20 19:37:36 | ID requested | |
| 1 | 2025-03-20 19:37:48 | announced | |
| ⏵ 2 | 2025-07-08 22:55:10 | announced | 2025-07-09: Add info. |
Publication List
| Kang Z, Yang M, Liu Y, Gui Y, Dong Y, Zhou H, Zhang Z, Li M, Fan H, Li Z, Lu J, Li J, Zhu R, Yin C, Liu B, Jiang F, Huang K, Sarapultsev A, Li F, Zhang G, Zhao L, Wang Y, Ning Y, Cheng X, Mohanta SK, Yin C, Luo S, Habenicht AJR, Hu D, Myocardial mitochondrial antiviral signaling protein promotes heart Ischemia-reperfusion injury via RIG-I signaling in mice. Nat Commun, 16(1):5101(2025) [pubmed] |
Keyword List
| submitter keyword: MAVS MIRI RIG-I |
Contact List
| Desheng Hu | |
|---|---|
| contact affiliation | Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| contact email | Desheng.Hu@hust.edu.cn |
| lab head | |
| Zhenyu Kang | |
| contact affiliation | Wuhan Union Medical College Hospital Huazhong University of Science and Technology |
| contact email | 364212978@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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