PXD062097
PXD062097 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Myocardial Mitochondrial Antiviral Signaling Protein Promotes Heart Ischemia-reperfusion Injury via RIG-I Signaling-proteomic sequencing |
| Description | Myocardial ischemia-reperfusion injury (MIRI) is a life-threatening complication of myocardial infarcts, with inner mitochondrial membrane protein dysfunction involved in MIRI-induced heart injury. The role of outer mitochondrial membrane protein MAVS is unknown. Here we show that MAVS expression increased in infarcted myocardium of wild-type (WT) mice. Global MAVS-knock-out (MAVS-KO) or myocardial-specific MAVS knockdown protects mice from acute and chronic MIRI, reducing apoptosis, leukocyte infiltration, etc. MIRI induces double-stranded RNA in affected myocardium, activating intracellular retinoic acid-inducible gene I (RIG-I) signaling, which led to MAVS aggregation for further non-canonical downstream signaling. MAVS aggregates recruit tumor necrosis factor associated factor family 6 (TRAF6) and transforming growth factor-β-activated kinase 1 (TAK1), activating mitogen-activated protein kinase (MAPK) pathway and apoptosis. MAVS-KO reduces -jun-NH2 terminal kinase (JNK) phosphorylation and apoptosis. JNK inhibition benefits WT mice and JNK agonist impairs protection in MAVS-KO mice. MIRI activates RIG-I/MAVS via TAK1/TRAF6-MAPK/JNK axis, suggesting new MIRI therapeutic targets to treat MIRI. |
| HostingRepository | iProX |
| AnnounceDate | 2025-03-20 |
| AnnouncementXML | Submission_2025-03-20_19:37:48.568.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhenyu Kang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-03-20 19:37:36 | ID requested | |
| ⏵ 1 | 2025-03-20 19:37:48 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: MAVS MIRI RIG-I |
Contact List
| Desheng Hu | |
|---|---|
| contact affiliation | Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| contact email | Desheng.Hu@hust.edu.cn |
| lab head | |
| Zhenyu Kang | |
| contact affiliation | Wuhan Union Medical College Hospital Huazhong University of Science and Technology |
| contact email | 364212978@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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