PXD062096
PXD062096 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Myocardial Mitochondrial Antiviral Signaling Protein Promotes Heart Ischemia-reperfusion Injury via RIG-I Signaling-mass spectrometry |
Description | Myocardial ischemia-reperfusion injury (MIRI) is a life-threatening complication of myocardial infarcts, with inner mitochondrial membrane protein dysfunction involved in MIRI-induced heart injury. The role of outer mitochondrial membrane protein MAVS is unknown. Here we show that MAVS expression increased in infarcted myocardium of wild-type (WT) mice. Global MAVS-knock-out (MAVS-KO) or myocardial-specific MAVS knockdown protects mice from acute and chronic MIRI, reducing apoptosis, leukocyte infiltration, etc. MIRI induces double-stranded RNA in affected myocardium, activating intracellular retinoic acid-inducible gene I (RIG-I) signaling, which led to MAVS aggregation for further non-canonical downstream signaling. MAVS aggregates recruit tumor necrosis factor associated factor family 6 (TRAF6) and transforming growth factor-β-activated kinase 1 (TAK1), activating mitogen-activated protein kinase (MAPK) pathway and apoptosis. MAVS-KO reduces -jun-NH2 terminal kinase (JNK) phosphorylation and apoptosis. JNK inhibition benefits WT mice and JNK agonist impairs protection in MAVS-KO mice. MIRI activates RIG-I/MAVS via TAK1/TRAF6-MAPK/JNK axis, suggesting new MIRI therapeutic targets to treat MIRI. |
HostingRepository | iProX |
AnnounceDate | 2025-03-20 |
AnnouncementXML | Submission_2025-03-20_19:36:03.016.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zhenyu Kang |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-03-20 19:35:49 | ID requested | |
⏵ 1 | 2025-03-20 19:36:03 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: MAVS RIG-I MIRI |
Contact List
Desheng Hu | |
---|---|
contact affiliation | Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
contact email | Desheng.Hu@hust.edu.cn |
lab head | |
Zhenyu Kang | |
contact affiliation | Wuhan Union Medical College Hospitai, Huazhong University of Science and Technology |
contact email | 364212978@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |