PXD062072

PXD062072 is an original dataset announced via ProteomeXchange.

Title	Proteomics on Inhibition of ceramide synthesis in the context of cachexia
Description	Cachexia is a metabolic wasting syndrome affecting most of cancer patients. Disturbed lipid metabolism is a cachexia hallmark, and our previous work has identified increased levels of circulating ceramides, bioactive lipids with established functions in metabolic diseases, as biomarkers for cachexia in mouse models and patients. Here, we demonstrate that elevated ceramides in cachexia arise from increased liver synthesis. We show that ceramides directly contribute to impaired mitochondrial function and energy homeostasis in cachexia target tissues. Targeting ceramide synthesis using myriocin, an approved compound targeting the key synthesis enzyme serine palmitoyltransferase (SPT), improved muscle atrophy in cachectic mice. Lastly, we demonstrate that key enzymes involved in ceramide production are also elevated in livers, but not other organs, of patients with cancer cachexia, correlating with disease severity. Our data place ceramides as novel contributors to metabolic dysfunction in cachexia and highlight the suitability of the ceramide synthesis pathway for therapeutic targeting.
HostingRepository	PRIDE
AnnounceDate	2026-02-24
AnnouncementXML	Submission_2026-02-24_07:47:33.487.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christine von Toerne
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-20 04:32:46	ID requested
⏵ 1	2026-02-24 07:47:34	announced

Dataset with its publication pending

submitter keyword: None

Maria Rohm
contact affiliation	Group leader at the Institute for Diabetes and Cancer, headed by Stephan Herzig, Helmholtz Munich
contact email	maria.rohm@helmholtz-munich.de
lab head
Christine von Toerne
contact affiliation	Helmholtz Zentrum München
contact email	vontoerne@helmholtz-muenchen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD062072

PRIDE project URI

• PRIDE
  1. PXD062072
     1. Label: PRIDE project
     2. Name: Proteomics on Inhibition of ceramide synthesis in the context of cachexia