PXD061951

PXD061951 is an original dataset announced via ProteomeXchange.

Title	Characterization of the crotonylome in septic heart
Description	Sepsis-induced myocardial dysfunction is associated with high mortality in sepsis. However, the underlying mechanisms of sepsis-induced myocardial dysfunction remain unclear. The heart is an energy-demanding organ. Under basal physiological conditions, cardiomyocytes rely primarily on energy provided by fatty acid oxidation. In this study, we identified a total of 3,579 proteins and 8,519 Kcr sites, averaging 2,794 proteins and 5,550 Kcr sites per sample. We established a deep learning model. The highest-ranked functional Kcr site was CPT1B K321cr. Multiple sequence alignment of CPT1B from Rattus norvegicus, Homo sapiens, and Mus musculus revealed high similarity among these protein sequences. Additionally, the functional prediction of pFKcr was validated by the evolutionary conservation of the rat CPT1B K321 site in mice and humans.
HostingRepository	iProX
AnnounceDate	2025-03-17
AnnouncementXML	Submission_2025-03-17_21:23:48.541.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tiening Zhang
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	N6-crotonyl-L-lysine
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-17 21:23:26	ID requested
⏵ 1	2025-03-17 21:23:48	announced

Dataset with its publication pending

submitter keyword: sepsis, crotonylome, LC-MS/MS, cardiomyocyte

Tiening Zhang
contact affiliation	Shengjing Hospital of China Medical University
contact email	cmuztn@vip.qq.com
lab head
Tiening Zhang
contact affiliation	Shengjing Hospital of China Medical University
contact email	cmuztn@vip.qq.com
dataset submitter

iProX dataset URI