PXD061867

PXD061867 is an original dataset announced via ProteomeXchange.

Title	Defining the interactome of ARID5B by AviTag protein pull-down coupled to quantitative mass spectrometry.
Description	Among the strongest associations with pediatric B-cell acute lymphoblastic leukemia (B-ALL) are risk non-coding variants localized in the intron of ARID5B (AT-rich interaction domain 5B), a poorly characterized DNA-binding protein. In this study, we defined the interactome of ARID5B by LC-MS/MS and identified transcriptional repressors HDAC1, HDAC2, MIER1 and C16ORF87 as interactors. Structural predictions revealed that ARID5B and its interactors assemble into a repressor complex. We further validated and characterized the molecular function of the ARID5B repressor complex in B cells.
HostingRepository	PRIDE
AnnounceDate	2026-05-19
AnnouncementXML	Submission_2026-05-19_13:13:07.960.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fabian Frommelt
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-14 16:38:12	ID requested
⏵ 1	2026-05-19 13:13:08	announced

Dataset with its publication pending

submitter keyword: transcriptional repressor complex,AviTag

Davide Seruggia
contact affiliation	St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
contact email	davide.seruggia@ccri.at
lab head
Fabian Frommelt
contact affiliation	CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
contact email	fabian.frommelt@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD061867

PRIDE project URI

• PRIDE
  1. PXD061867
     1. Label: PRIDE project
     2. Name: Defining the interactome of ARID5B by AviTag protein pull-down coupled to quantitative mass spectrometry.