PXD061758

PXD061758 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteogenomic subtyping of acute myeloid leukemia and ex-vivo drug response profiling for precision therapies.
Description	We have performed a comprehensive proteomic analysis of clinical patient samples of acute myeloid leukemia (AML) alongside genome-, transcriptome- and ex-vivo drug response profiling.
HostingRepository	PRIDE
AnnounceDate	2026-03-26
AnnouncementXML	Submission_2026-03-26_09:43:05.134.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rozbeh Jafari
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-12 06:05:13	ID requested
⏵ 1	2026-03-26 09:43:06	announced

Publication List

10.1038/s41698-026-01363-8;
Struyf N, Gezelius H, Lundmark A, Barizza C, Ploeger H, Rico Pizarro L, Vesterlund M, Mermelekas G, Ö, sterroos A, Bohlin A, Bengtz, é, n S, Hamberg Levedahl K, Jafari R, Orre LM, Lehti, ö J, Ö, stling P, Seashore-Ludlow B, Nordlund J, Lehmann S, Kallioniemi O, Erkers T, Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics. NPJ Precis Oncol, 10(1):(2026) [pubmed]

10.1038/s41698-026-01363-8;

Struyf N, Gezelius H, Lundmark A, Barizza C, Ploeger H, Rico Pizarro L, Vesterlund M, Mermelekas G, Ö, sterroos A, Bohlin A, Bengtz, é, n S, Hamberg Levedahl K, Jafari R, Orre LM, Lehti, ö J, Ö, stling P, Seashore-Ludlow B, Nordlund J, Lehmann S, Kallioniemi O, Erkers T, Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics. NPJ Precis Oncol, 10(1):(2026) [pubmed]

Keyword List

submitter keyword: AML, cancer, proteomics, leukemia, drug screening, therapy

submitter keyword: AML, cancer, proteomics, leukemia, drug screening, therapy

Contact List

Prof Janne
contact affiliation	Department of Oncology-Pathology, Karolinska Institutet and Science for Life Laboratory (lab head)
contact email	janne.lehtio@ki.se
lab head
Rozbeh Jafari
contact affiliation	Karolinska Institutet
contact email	rozbeh.jafari@ki.se
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD061758
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD061758

PRIDE project URI

Repository Record List

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