PXD061746

PXD061746 is an original dataset announced via ProteomeXchange.

Title	Impaired aggrephagy,abnormal vesicular trafficking and cellular stress, lead to protein aggregation,neurodegeneration and synaptic dysfunction in cerebellar vermis of children and adults with idiopathic autism
Description	Autism spectrum disorder (ASD) is a debilitating neurodevelopmental disorder with genetic and environmental etiologies involving several brain areas exhibiting abnormalities of cognition and social behavior. Previous work showed involvement of synaptic abnormalities in dorsolateral prefrontal cortex. We hypothesized whether similar synaptic proteins were involved in pathology of cerebellar vermis of children and adults with ASD. Subcellular fractions of synaptosomes from cerebellar vermal cortices of age-, brain area-, and postmortem-interval- matched samples from children and adults with idiopathic ASD vs. controls were subjected to HPLC-tandem mass spectrometry. Analysis of proteomic data in cerebellar vermis showed common and distinct effects of ASD on protein- and pathway-enrichment for children vs. adults.
HostingRepository	PRIDE
AnnounceDate	2025-08-25
AnnouncementXML	Submission_2025-08-24_20:28:48.871.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD061746
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Arthur Eschenlauer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-12 01:42:41	ID requested
⏵ 1	2025-08-24 20:28:49	announced

Fatemi SH, Folsom TD, Eschenlauer A, Chekouo T, Impaired Aggrephagy, Interrupted Vesicular Trafficking, and Cellular Stress, Lead to Protein Aggregation, and Synaptic Dysfunction in Cerebellum of Children and Adults with Idiopathic Autism. Cerebellum, 24(5):140(2025) [pubmed]

10.1007/s12311-025-01880-5;

10.6019/PXD061746;

submitter keyword: LC-MS/MS, proteomics, vermis, vesicular transport, Human, cerebellum, Autism, protein misfolding, ASD, proteostasis, neurodegeneration

S Hossein Fatemi
contact affiliation	Bernstein Professor Emeritus in Adult Psychiatry Department of Psychiatry and Behavioral Sciences University of Minnesota Medical School Minneapolis, Minnesota, USA
contact email	fatem002@umn.edu
lab head
Arthur Eschenlauer
contact affiliation	University of Minnesota, retired
contact email	eschen@alumni.princeton.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD061746

PRIDE project URI

• PRIDE
  1. PXD061746
     1. Label: PRIDE project
     2. Name: Impaired aggrephagy,abnormal vesicular trafficking and cellular stress, lead to protein aggregation,neurodegeneration and synaptic dysfunction in cerebellar vermis of children and adults with idiopathic autism