PXD061722

PXD061722 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic and phosphoproteomic profiling of Sh3rf3-deficient ASD mouse model via 6Plex-TMT and phosphoproteomic
Description	This study aims to systematically investigate the molecular mechanisms underlying autism spectrum disorder (ASD) by analyzing the proteome and phosphoproteome of a Sh3rf3-deficient mouse model. SH3RF3 (SH3 domain-containing RING finger protein 3) is implicated in synaptic regulation pathways, yet its role in ASD remains poorly understood. Through integrated quantitative proteomics and phosphoproteomics, we seek to:Identify dysregulated proteins and phosphorylation events in Sh3rf3 knockout mice.Uncover signaling pathways and post-translational modifications (PTMs) associated with ASD pathophysiology.Provide a resource for understanding synaptic protein networks regulated by SH3RF3.
HostingRepository	PRIDE
AnnounceDate	2026-03-23
AnnouncementXML	Submission_2026-03-22_18:03:17.340.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuting Yuan
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-11 13:52:06	ID requested
⏵ 1	2026-03-22 18:03:18	announced

10.1038/s41380-025-03370-w;

Yuan Y, Li Y, Yang F, Jiang Y, Ding Y, Xiao Y, Zhu X, Shu X, Huang X, Wang Y, Zhang S, Sun J, Xu Z, Sh3rf3 Deficiency drives autism-like behaviors via presynaptic dysfunction in mice. Mol Psychiatry, 31(4):2202-2215(2026) [pubmed]

submitter keyword: prefrontal cortex,Mouse, MS, SH3RF3

Zhiheng Xu
contact affiliation	Institute of Genetics & Developmental Biology, Chinese Academy of Sciences
contact email	zhxu@genetics.ac.cn
lab head
Yuting Yuan
contact affiliation	Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
contact email	yuanyuting@genetics.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD061722

PRIDE project URI

• PRIDE
  1. PXD061722
     1. Label: PRIDE project
     2. Name: Quantitative proteomic and phosphoproteomic profiling of Sh3rf3-deficient ASD mouse model via 6Plex-TMT and phosphoproteomic