PXD061721 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Low-Abundance Serum Protein Biomarker Candidates for HCC in Patients with Liver Cirrhosis |
| Description | In this study, we employed both untargeted and targeted analysis of low abundance serum proteins to identify potential biomarkers for HCC. We employed a two-phase proteomics approach to identify low abundance serum proteins as potential biomarkers for HCC.The first phase involved DDA-based untargeted proteomics analysis of serum samples from HCC cases and patients with CIRR. Label-free quantification (LFQ) was performed to identify statistically significantly differentially expressed proteins. In the second phase, a targeted proteomics analysis was conducted using PRM on the same cohort of samples targeting proteins selected in the untargeted study along with AFP and other previously reported biomarker candidates. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-15 |
| AnnouncementXML | Submission_2026-06-15_00:47:21.577.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Habtom Ressom |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-11 13:33:32 | ID requested | |
| ⏵ 1 | 2026-06-15 00:47:22 | announced | |
Publication List
| Sajid MS, Varghese RS, Kroemer A, Ressom HW, Low-Abundance Serum Protein Biomarker Candidates for HCC in Patients with Liver Cirrhosis. J Proteome Res, 24(7):3656-3665(2025) [pubmed] |
| 10.1021/acs.jproteome.5c00231; |
Keyword List
| submitter keyword: nano-LC-MS/MS, Low Abundance Protein, Serum,LiLiver cancer, Biomarker |
Contact List
| Habtom Ressom |
|---|
| contact affiliation | Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC, USA |
| contact email | hwr@georgetown.edu |
| lab head | |
| Habtom Ressom |
|---|
| contact affiliation | Georgetown University |
| contact email | hwr@georgetown.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD061721 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061721
- Label: PRIDE project
- Name: Low-Abundance Serum Protein Biomarker Candidates for HCC in Patients with Liver Cirrhosis
