PXD061700

PXD061700 is an original dataset announced via ProteomeXchange.

Title	Mass spectrometry analysis of MTH1 inhibitor TH1579 in keratinocytes
Description	MutT Homolog 1 (MTH1) prevents the incorporation of oxidized nucleotide triphosphates into genomic DNA as an antioxidant defense mechanism. The induced expression of MTH1 in psoriatic skin highlights the altered redox regulation and supports the idea of targeted intervention. Thus, MTH1 inhibition can be a novel promising treatment modality for psoriasis. Mass spectrometry-based proteomics was used to understand the MTH1i-induced molecular alterations in human keratinocytes. The expression of identified candidate proteins and MTH1 were further validated using quantitative real-time PCR.
HostingRepository	PRIDE
AnnounceDate	2026-02-09
AnnouncementXML	Submission_2026-02-08_16:07:24.176.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lavanya Moparthi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-11 07:09:30	ID requested
⏵ 1	2026-02-08 16:07:25	announced

10.3390/ijms26157174;

Bivik Eding C, K, ö, hler I, Moparthi L, Sj, ö, gren F, Andersson B, Das D, Verma D, Scobie M, Warpman Berglund U, Enerb, ä, ck C, Topical MTH1 Inhibition Suppresses SKP2-WNT5a-Driven Psoriatic Hyperproliferation. Int J Mol Sci, 26(15):(2025) [pubmed]

submitter keyword: keratinocytes, TH1579, psoriasis, Mass spectrometry,MTH1i

Charlotta Enerbäck
contact affiliation	Ingrid Asp Psoriasis Research Center, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
contact email	Charlotta.enerback@liu.se
lab head
Lavanya Moparthi
contact affiliation	LINKÖPING UNIVERSITY
contact email	lavanya.moparthi@liu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD061700

PRIDE project URI

• PRIDE
  1. PXD061700
     1. Label: PRIDE project
     2. Name: Mass spectrometry analysis of MTH1 inhibitor TH1579 in keratinocytes