PXD061699 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Psychoactive contaminants alter fish sperm function via neurotransmitter signaling |
| Description | The widespread occurrence of psychoactive pollutants in surface waters raises concerns for aquatic ecosystems, yet impacts beyond behavioral disruption remain poorly understood. Designed to target neurotransmitter (NT) systems in humans, these contaminants may also interfere with conserved NT pathways in fish. Here we provide the first evidence that fish sperm contain NTs and their receptors, indicating an active NT-mediated signaling system essential for sperm function. Using European perch (Perca fluviatilis) exposed to environmentally relevant concentrations of methamphetamine, we quantified NTs in brain, gonads, and sperm, assessed tissue-specific bioaccumulation, and evaluated sperm performance. Methamphetamine accumulated across tissues, modified NT profiles, and altered sperm motility and velocity. These findings reveal a previously unrecognized pathway of reproductive vulnerability, identifying NT signaling in sperm as a novel target of psychoactive pollutants with potential implications for fertilization success and population resilience in aquatic ecosystems. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-12 |
| AnnouncementXML | Submission_2025-12-12_03:06:14.557.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Filip Dyčka |
| SpeciesList | scientific name: Perca fluviatilis; NCBI TaxID: NEWT:8168; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-11 07:09:05 | ID requested | |
| ⏵ 1 | 2025-12-12 03:06:15 | announced | |
Publication List
Keyword List
Contact List
| Ganna Fedorova |
|---|
| contact affiliation | Faculty of Fisheries and Protection of Water, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, University of South Bohemia in Ceske Budejovice, Czech Republic |
| contact email | gfedorova@frov.jcu.cz |
| lab head | |
| Filip Dyčka |
|---|
| contact affiliation | University of South Bohemia in Ceske Budejovice
Faculty of Science
Branisovska 1760
Ceske Budejovice |
| contact email | dycka@mail.muni.cz |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD061699 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061699
- Label: PRIDE project
- Name: Psychoactive contaminants alter fish sperm function via neurotransmitter signaling
