PXD061694 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight |
Description | Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T and NK-cells in 124 dengue patients using flow cytometry and single-cell RNA-sequencing. We show that T/NK-cell signatures early in infection discriminate patients who will progressdevelop to severe dengue (SD) from those who do not. These signatures are exacerbated in In patients with overweight/obesity these signatures are exacerbated compared to healthy weight patients, supporting their increased susceptibility to SD. In SD, CD4+/CD8+ T-cells and NK-cells display increased co-inhibitory receptor expression and decreased cytotoxic capacity potential compared to non-SD. Using transcriptional and proteomics approaches we demonstrate decreased Furthermore, type-I Interferon signalling is downregulatedresponses in SD, suggesting defective innate immunity virus-sensing mechanisms may underlie NK/T-cell dysfunction. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-21 |
AnnouncementXML | Submission_2025-05-21_08:05:30.896.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Andrew Davidson |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex reporter+balance reagent acylated N-terminal; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2025-03-11 04:39:11 | ID requested | |
⏵ 1 | 2025-05-21 08:05:31 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: dengue, CD4+ T-cells, CD8+ T-cells, co-inhibitory receptors, cytotoxic cells, severe dengue biomarkers,NK-cells, type-I IFN |
Contact List
Laura Rivino |
contact affiliation | School of Cellular and Molecular Medicine University of Bristol Biomedical Sciences Building University Walk Bristol BS8 1TD, UK |
contact email | laura.rivino@bristol.ac.uk |
lab head | |
Andrew Davidson |
contact affiliation | University of Bristol, Bristol UK |
contact email | andrew.davidson@bristol.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061694
- Label: PRIDE project
- Name: Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight