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PXD061694

PXD061694 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEarly NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight
DescriptionDengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T and NK-cells in 124 dengue patients using flow cytometry and single-cell RNA-sequencing. We show that T/NK-cell signatures early in infection discriminate patients who will progressdevelop to severe dengue (SD) from those who do not. These signatures are exacerbated in In patients with overweight/obesity these signatures are exacerbated compared to healthy weight patients, supporting their increased susceptibility to SD. In SD, CD4+/CD8+ T-cells and NK-cells display increased co-inhibitory receptor expression and decreased cytotoxic capacity potential compared to non-SD. Using transcriptional and proteomics approaches we demonstrate decreased Furthermore, type-I Interferon signalling is downregulatedresponses in SD, suggesting defective innate immunity virus-sensing mechanisms may underlie NK/T-cell dysfunction.
HostingRepositoryPRIDE
AnnounceDate2025-05-21
AnnouncementXMLSubmission_2025-05-21_08:05:30.896.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAndrew Davidson
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex reporter+balance reagent acylated N-terminal; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-03-11 04:39:11ID requested
12025-05-21 08:05:31announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: dengue, CD4+ T-cells, CD8+ T-cells, co-inhibitory receptors, cytotoxic cells, severe dengue biomarkers,NK-cells, type-I IFN
Contact List
Laura Rivino
contact affiliationSchool of Cellular and Molecular Medicine University of Bristol Biomedical Sciences Building University Walk Bristol BS8 1TD, UK
contact emaillaura.rivino@bristol.ac.uk
lab head
Andrew Davidson
contact affiliationUniversity of Bristol, Bristol UK
contact emailandrew.davidson@bristol.ac.uk
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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