PXD061686 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | LncRNA NEAT1 promotes immunosuppression in gastric cancer by maintaining the m6A methylation of SEMA3A in CAFs via exosomes under endoplasmic reticulum stress |
| Description | Endoplasmic reticulum stress (ERS) regulates the function of immune cells in the tumor microenvironment and suppresses the antitumor immune response. In order to formulate the TME of ERS-GC, we cocultured the human CAFs with the supernatant of human gastric cancer cells stimulated by TM. Mass spectrometry sequencing revealed that ERS state regulated the overexpression of 58 proteins and downregulation of the expression of 56 proteins in CAFs, including m6A-modified proteins and SEMA3A, an immunosuppression-related protein. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-13 |
| AnnouncementXML | Submission_2026-04-12_16:15:21.971.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | 栋新 奚 |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-11 02:50:24 | ID requested | |
| ⏵ 1 | 2026-04-12 16:15:22 | announced | |
Publication List
| Xu Y, Xu R, Chen Z, Zhou H, Liao J, Ji K, Yang S, Zhong X, Li Y, Xi D, Zhang Q, Zhao L, Zuo Q, A methylation of SEMA3A in CAFs. Mol Cancer, 25(1):(2026) [pubmed] |
| 10.1186/s12943-026-02613-w; |
Keyword List
| submitter keyword: Humon;SGC7901;Endoplasmic reticulum stress (ERS) |
Contact List
| Youqin Xu |
|---|
| contact affiliation | The Fifth Affiliated Hospital of Guangzhou Medical University |
| contact email | 2023991033@gzhmu.edu.cn |
| lab head | |
| 栋新 奚 |
|---|
| contact affiliation | Guangzhou medical university |
| contact email | xidongxin111@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD061686 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061686
- Label: PRIDE project
- Name: LncRNA NEAT1 promotes immunosuppression in gastric cancer by maintaining the m6A methylation of SEMA3A in CAFs via exosomes under endoplasmic reticulum stress
