PXD061685 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of Sh3rf3-interacting proteins in mouse prefrontal cortex by immunoprecipitation mass spectrometry |
| Description | Sh3rf3 is an ASD-associated gene,Sh3rf3 deficiency reduces excitatory synaptic strength in prefrontal cortex and decreases the readily releasable vesicle pool and attenuated vesicle replenishment.To delve into the underlying mechanisms for impaired excitatory transmission, we performed immunoprecipitation mass spectrometry (IP-MS) in Sh3rf3-3×flag knock-in mice we generated. Gene Ontology analysis of proteins that interacted with SH3RF3 indicated that they were highly associated with synaptic transmission and vesicle recycling. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-23 |
| AnnouncementXML | Submission_2026-03-22_17:15:05.255.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuting Yuan |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-11 02:41:46 | ID requested | |
| ⏵ 1 | 2026-03-22 17:15:06 | announced | |
Publication List
| 10.1038/s41380-025-03370-w; |
| Yuan Y, Li Y, Yang F, Jiang Y, Ding Y, Xiao Y, Zhu X, Shu X, Huang X, Wang Y, Zhang S, Sun J, Xu Z, Sh3rf3 Deficiency drives autism-like behaviors via presynaptic dysfunction in mice. Mol Psychiatry, 31(4):2202-2215(2026) [pubmed] |
Keyword List
| submitter keyword: prefrontal cortex,Mouse,IP-MS, SH3RF3 |
Contact List
| Zhiheng Xu |
|---|
| contact affiliation | Institute of Genetics & Developmental Biology, Chinese Academy of Sciences |
| contact email | zhxu@genetics.ac.cn |
| lab head | |
| Yuting Yuan |
|---|
| contact affiliation | Institute of Genetics and Developmental Biology, Chinese Academy of Sciences |
| contact email | yuanyuting@genetics.ac.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD061685 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061685
- Label: PRIDE project
- Name: Identification of Sh3rf3-interacting proteins in mouse prefrontal cortex by immunoprecipitation mass spectrometry
