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PXD061679

PXD061679 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA Comparative Serum Proteomic Analysis in Large-Artery Atherosclerosis Patients Progressing to Acute Ischemic Stroke: Discovery of Predictive Biomarker Panels
DescriptionTo predict acute ischemic stroke (AIS) in large-artery atherosclerosis (LAA), we combined serum proteomics with machine learning to identify diagnostic biomarkers. Using a dual-cohort design, we analyzed proteins and validated targets through advanced proteomic techniques. Machine learning identified two protein panels: one distinguishing AIS from LAA and another differentiating AIS/LAA from healthy controls. These panels capture dynamic pathophysiological processes, offering scalable tools for stroke prediction in high-risk LAA populations, surpassing conventional anatomical assessments.
HostingRepositoryiProX
AnnounceDate2025-03-11
AnnouncementXMLSubmission_2025-03-10_22:45:06.965.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYueting Xiong
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-03-10 22:43:58ID requested
12025-03-10 22:45:07announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Large-artery atherosclerosis, Ischemic stroke, Serum proteomics, Biomarker panel, Risk stratification
Contact List
Ningshao Xia
contact affiliationState Key Laboratory of Vaccines for InfectiousDiseases, Xiang AnBiomedicine Laboratory
contact emailnsxia@xmuedu.cn
lab head
Yueting Xiong
contact affiliationXiang An Biomedicine Laboratory
contact emailytxiong@xmu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI