PXD061679
PXD061679 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | A Comparative Serum Proteomic Analysis in Large-Artery Atherosclerosis Patients Progressing to Acute Ischemic Stroke: Discovery of Predictive Biomarker Panels |
Description | To predict acute ischemic stroke (AIS) in large-artery atherosclerosis (LAA), we combined serum proteomics with machine learning to identify diagnostic biomarkers. Using a dual-cohort design, we analyzed proteins and validated targets through advanced proteomic techniques. Machine learning identified two protein panels: one distinguishing AIS from LAA and another differentiating AIS/LAA from healthy controls. These panels capture dynamic pathophysiological processes, offering scalable tools for stroke prediction in high-risk LAA populations, surpassing conventional anatomical assessments. |
HostingRepository | iProX |
AnnounceDate | 2025-03-11 |
AnnouncementXML | Submission_2025-03-10_22:45:06.965.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yueting Xiong |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-03-10 22:43:58 | ID requested | |
⏵ 1 | 2025-03-10 22:45:07 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Large-artery atherosclerosis, Ischemic stroke, Serum proteomics, Biomarker panel, Risk stratification |
Contact List
Ningshao Xia | |
---|---|
contact affiliation | State Key Laboratory of Vaccines for InfectiousDiseases, Xiang AnBiomedicine Laboratory |
contact email | nsxia@xmuedu.cn |
lab head | |
Yueting Xiong | |
contact affiliation | Xiang An Biomedicine Laboratory |
contact email | ytxiong@xmu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |