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PXD061628

PXD061628 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	CENPU promotes tumorigenesis and stem cell properties in triple-negative breast cancer by suppressing lysosomal furin degradation
Description	Centromere protein U (CENPU), which is a critical component of the centromere complex, is involved in the cell filament. However, limited research has been conducted on the relationship between CENPU expression and tumors. Immunohistochemical assessment of clinical samples and analysis of TCGA data revealed a positive correlation between CENPU expression and the degree of invasiveness in breast cancer cells. CENPU promoted stem-cell-like behavior and tumorigenicity and induced malignancy in breast cancer cells. Mechanistically, CENPU promoted furin activity by inhibiting its lysosomal degradation. Furin, which is a precursor-processing enzyme of nerve growth factor (NGF), promoted the conversion of proNGF to NGF which could promote breast cancer stem cells in triple-negative breast cancers. . A tumorigenesis assay conducted in a mouse model showed that CENPU promoted tumorigenesis, and treatment with a furin inhibitor suppressed this effect. Our findings revealed that CENPU plays a critical role in furin-mediated signaling responsible for tumorigenesis. Therefore, CENPU may be a novel molecular target in triple-negative breast cancer.
HostingRepository	iProX
AnnounceDate	2025-03-08
AnnouncementXML	Submission_2025-03-12_01:41:08.869.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shujuan Sun
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-09 20:20:19	ID requested
⏵ 1	2025-03-12 01:41:09	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: CENPU, breast cancer

Contact List

Dongdong Zhou
contact affiliation	Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, China, 250117, PR China
contact email	wasabi1214@163.com
lab head
Shujuan Sun
contact affiliation	Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, China, 250117, PR China
contact email	ssj0411@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI