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PXD061574

PXD061574 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma
Descriptionwe show that VSVΔ51 has higher antitumor efficacy for hepatocellular carcinoma in the absence of microbiota in female mouse models. VSVΔ51 infection causes microbiota dysbiosis, increasing most of the gut bacteria abundance, while decreasing the commensal Lactobacillus. VSVΔ51 reduced intestinal expression of SLC20A1 that binds to Lactobacillus acidophilus (L. acidophilus) CdpA cell wall protein through IL6-JAK-STAT3 signaling, thereby attenuating attachment and colonization of L. acidophilus.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-07_07:26:42.489.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterjiayu ZHANG
SpeciesList scientific name: Lactobacillus acidophilus DSM 9126; NCBI TaxID: 1226676;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro 2
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-03-07 03:44:03ID requested
12025-05-07 07:26:43announced
Publication List
Zhang J, Yang J, Luo J, Wu W, Luo H, Wei W, Lyu H, Wang Y, Yi H, Zhang Y, Fan Z, Lyu H, Kanakaveti VP, Qin B, Yuan P, Yang R, Zhang H, Zuo T, Felsher DW, Lee MH, Li K, Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma. Nat Commun, 16(1):3315(2025) [pubmed]
10.1038/s41467-025-58407-z;
Keyword List
submitter keyword: LC-MS,oncolytic virus, mice, colon
Contact List
Jiayu Zhang
contact affiliationSun Yat-sen University
contact emailzhangjy226@mail2.sysu.edu.cn
lab head
jiayu ZHANG
contact affiliationSun Yat-sen University
contact emailzhangjy226@mail2.sysu.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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