PXD061574 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma |
Description | we show that VSVΔ51 has higher antitumor efficacy for hepatocellular carcinoma in the absence of microbiota in female mouse models. VSVΔ51 infection causes microbiota dysbiosis, increasing most of the gut bacteria abundance, while decreasing the commensal Lactobacillus. VSVΔ51 reduced intestinal expression of SLC20A1 that binds to Lactobacillus acidophilus (L. acidophilus) CdpA cell wall protein through IL6-JAK-STAT3 signaling, thereby attenuating attachment and colonization of L. acidophilus. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-07_07:26:42.489.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | jiayu ZHANG |
SpeciesList | scientific name: Lactobacillus acidophilus DSM 9126; NCBI TaxID: 1226676; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro 2 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2025-03-07 03:44:03 | ID requested | |
⏵ 1 | 2025-05-07 07:26:43 | announced | |
Publication List
Zhang J, Yang J, Luo J, Wu W, Luo H, Wei W, Lyu H, Wang Y, Yi H, Zhang Y, Fan Z, Lyu H, Kanakaveti VP, Qin B, Yuan P, Yang R, Zhang H, Zuo T, Felsher DW, Lee MH, Li K, Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma. Nat Commun, 16(1):3315(2025) [pubmed] |
10.1038/s41467-025-58407-z; |
Keyword List
submitter keyword: LC-MS,oncolytic virus, mice, colon |
Contact List
Jiayu Zhang |
contact affiliation | Sun Yat-sen University |
contact email | zhangjy226@mail2.sysu.edu.cn |
lab head | |
jiayu ZHANG |
contact affiliation | Sun Yat-sen University |
contact email | zhangjy226@mail2.sysu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD061574 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061574
- Label: PRIDE project
- Name: Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma