PXD061502

PXD061502 is an original dataset announced via ProteomeXchange.

Title	The urinary proteome differs with the presence and type of breast cancer
Description	Despite the advancements in screening and treatment, the incidence of breast cancer (BC) and associated mortalityare projected to increase. Therefore, developing a companion diagnostic for BC remains important. To explore the urinary proteome for potential biomarkers for BC.  A total of 130 participants were recruited for this study which categorised into four groups; (1) newly diagnosed breast cancer (BC) n=46, (2) benign breast disease (BBD) n=36, (3) symptom control (SC) n=30 and (4) healthy control (HC) n=18. The BC class sub-divided in pre-invasive: ductal carcinoma in situ (DCIS) (n=3), invasive ductal carcinoma (IDC) (n=23) and IDC accompanied DCIS (n=8) classes. Purified urinary proteins were analysed using a bottom-up data dependent acquisition proteomics approach. Protein identifications and abundances were generated using Thermo Scientific TM Proteome Discoverer TM with statistical analyses were performed via open-source software platforms and databases; MetaboAnalyst v6.0, DAVID and STRING v12.0.
HostingRepository	PRIDE
AnnounceDate	2025-12-15
AnnouncementXML	Submission_2025-12-14_19:51:11.153.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nur Aimi Aliah Zainurin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-05 06:52:43	ID requested
⏵ 1	2025-12-14 19:51:12	announced

10.1021/acs.jproteome.5c00229;

Zainurin NAA, Morphew RM, Ganti A, Ivanova D, Gate T, Tench H, Phillips H, Pennick M, Mur LAJ, The Urinary Proteome Differs with the Presence and Type of Breast Cancer. J Proteome Res, 24(12):5932-5947(2025) [pubmed]

submitter keyword: Proteomic,Breast cancer, Urine

Luis Mur
contact affiliation	Aberystwyth University
contact email	lum@aber.ac.uk
lab head
Nur Aimi Aliah Zainurin
contact affiliation	Aberystwyth University
contact email	naz4@aber.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD061502
     1. Label: PRIDE project
     2. Name: The urinary proteome differs with the presence and type of breast cancer