PXD061501

PXD061501 is an original dataset announced via ProteomeXchange.

Title	Effect of the DPP-4 inhibitor Linagliptin on Heart Proteome in Mice Fed Normal and High Fat Diets: Gender-Related Metabolic Responses
Description	The dipeptidyl peptidase-4 (DPP-4) inhibitor Linagliptin is known for its role in glucose metabolism and potential cardioprotective effects. This study investigated the cardiac proteome of male and female C57BL/6N mice fed either a normal or high-fat diet, with or without Linagliptin treatment, using a label-free proteomic approach. The analysis revealed significant sex-related metabolic responses, affecting lipid metabolism, oxidative stress, and insulin signaling pathways. Notably, Linagliptin modulated mitochondrial and inflammatory processes, suggesting a potential role in improving cardiac function in obesity. These findings highlight novel biomarkers and molecular mechanisms underlying the cardiometabolic effects of DPP-4 inhibition.
HostingRepository	PRIDE
AnnounceDate	2026-08-28
AnnouncementXML	Submission_2026-08-28_10:45:55.821.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Simona Nonnis
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-05 06:49:16	ID requested
⏵ 1	2026-08-28 10:45:56	announced

10.1016/J.NUMECD.2026.104956;

submitter keyword: Proteomics, nano LC-MS/MS

elisa maffioli
contact affiliation	DIVAS, Department of Veterinary Medicine and Animal Science
contact email	elisa.maffioli@unimi.it
lab head
Simona Nonnis
contact affiliation	University of Milan
contact email	simona.nonnis@unimi.it
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD061501
     1. Label: PRIDE project
     2. Name: Effect of the DPP-4 inhibitor Linagliptin on Heart Proteome in Mice Fed Normal and High Fat Diets: Gender-Related Metabolic Responses