PXD061494 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Global profiling of Protein Lysine Lactylation in Mouse Cardiac Hypertrophy |
| Description | In our study, we performed quantitative proteomics and Kla PTM analysis to investigate the alterations in protein lysine lactylation in a mouse model of cardiac hypertrophy. The results identified 159 Kla-modified sites across 80 proteins, with 72 proteins showing increased Kla levels in hypertrophic hearts. These modifications were primarily localized in mitochondrial and sarcomeric proteins, highlighting their roles in energy metabolism and cardiac remodeling. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-06_16:10:48.910.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Wengen Zhu |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | acetylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-03-05 01:02:43 | ID requested | |
| ⏵ 1 | 2026-09-06 16:10:50 | announced | |
Publication List
| Zhu W, Guo S, Yang Y, Dong Y, Liu C, Chen C, Global Profiling of Protein Lysine Lactylation in Mouse Cardiac Hypertrophy: A Lactylome Analysis. J Cardiovasc Dev Dis, 13(7):(2026) [pubmed] |
| 10.3390/jcdd13070297; |
Keyword List
| ProteomeXchange project tag: Cardiovascular (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project |
| submitter keyword: lactylation, cardiac hypertrophy,Mouse, heart failure |
Contact List
| Wengen Zhu |
|---|
| contact affiliation | The First Affiliated Hospital of Sun Yat-sen university |
| contact email | 18170044224@163.com |
| lab head | |
| Wengen Zhu |
|---|
| contact affiliation | The First Affiliated Hosptial of Sun Yat-sen university |
| contact email | 18170044224@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD061494 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061494
- Label: PRIDE project
- Name: Global profiling of Protein Lysine Lactylation in Mouse Cardiac Hypertrophy
