PXD061454

PXD061454 is an original dataset announced via ProteomeXchange.

Title	MDM2 influenced chromatin-associated phospho-peptides in T47D cells
Description	Employing a stable isotope labeling in cell culture analysis in T47D breast cancer cells (expressing mtp53 L194F), we uncovered several chromatin-associated DNA replication and repair factors as MDM2-regulated (by MDM2 inducible knock-down) phosphoproteins, including 53BP1
HostingRepository	PRIDE
AnnounceDate	2025-07-14
AnnouncementXML	Submission_2025-07-13_16:06:39.235.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhuoning Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-04 06:02:35	ID requested
⏵ 1	2025-07-13 16:06:40	announced

10.1093/nar/gkaf627;

Ellison V, Polotskaia A, Xiao G, Leybengrub P, Lee R, Qiu W, Hendrickson RC, Hu W, Bargonetti J, A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin. Nucleic Acids Res, 53(13):(2025) [pubmed]

submitter keyword: chromatin-associated, phospho-peptides,MDM2, 53BP1

Jill Bargonetti-Chavarria
contact affiliation	City University of New York (CUNY) Hunter College, Chair of the Molecular Cellular and Developmental PhD subprogram at the CUNY Graduate Center
contact email	Jill.Bargonetti-chavarria81@login.cuny.edu
lab head
Zhuoning Li
contact affiliation	MSKCC
contact email	liz2@mskcc.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD061454

PRIDE project URI

• PRIDE
  1. PXD061454
     1. Label: PRIDE project
     2. Name: MDM2 influenced chromatin-associated phospho-peptides in T47D cells