PXD061439

PXD061439 is an original dataset announced via ProteomeXchange.

Title	Tissue-specific regulation of fatty acid metabolism in a mouse model of isolated complex I deficiency
Description	This study investigates tissue-specific changes in fatty acid metabolism in a mouse model of isolated complex I deficiency (ICD). Using mass spectrometry-based proteomics, the study examines protein expression changes in the brainstem, cerebellum, olfactory bulb, heart, kidney, and liver of Ndufs4 KO mice. The findings reveal that metabolic adaptations in fatty acid metabolism in response to ICD are tissue-specific and often opposing, indicating a complex compensatory response to mitochondrial dysfunction. Understanding these differential adaptations could inform future treatment targets for mitochondrial disorder
HostingRepository	PRIDE
AnnounceDate	2025-07-21
AnnouncementXML	Submission_2025-07-20_16:05:22.329.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sibonelo Glen Khumalo
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-04 02:23:11	ID requested
⏵ 1	2025-07-20 16:05:23	announced

Khumalo SG, Lindeque JZ, Venter M, Tissue-Specific Regulation of Fatty Acid Metabolism in a Mouse Model of Isolated Complex I Deficiency. Proteomics, 25(13):e13969(2025) [pubmed]

10.1002/pmic.13969;

submitter keyword: SWATH-MS,Mitochondrial disease, Ndufs4 KO, Fatty acid metabolism

Marianne Pretorius
contact affiliation	North-West Univesrity, Biomedical and Molecular MetabolismResearch(BioMMet)
contact email	Marianne.Pretorius@nwu.ac.za
lab head
Sibonelo Glen Khumalo
contact affiliation	Focus Area for Human Metabolomics
contact email	31773095@mynwu.ac.za
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD061439

PRIDE project URI

• PRIDE
  1. PXD061439
     1. Label: PRIDE project
     2. Name: Tissue-specific regulation of fatty acid metabolism in a mouse model of isolated complex I deficiency