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PXD061433

PXD061433 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTargeting CD37 promotes phagocytosis against multi cancer cell
DescriptionMacrophages play vital roles in innate and adaptive immunity, and their indispensable functions are accomplished by phagocytosis and antigen presentation. Great efforts have been made to explore the potential mechanism of action of potential phagocytosis checkpoints. However, the use of a systematic checkpoint scanning strategy is far from satisfactory. We thus established an in vitro phagocytosis assay using primary healthy donors’ macrophages and breast cancer cells. Equal numbers of cells were sorted and subjected to ribosome profiling, and immune system-specific checkpoints were ultimately identified. CD37 was dramatically downregulated in phagocytic macrophages and targeting CD37 with a specific antibody promoted phagocytosis of multiple cancer cells. Tumorous macrophage migration inhibitory factor (MIF) directly binds to CD37 and promotes the recruitment of SHP1. Targeting CD37 enhances the efficacy of CD47 in vivo and in vitro. In all, our study identified a previously unidentified phagocytosis checkpoint and provided new potential for precise therapy.
HostingRepositoryiProX
AnnounceDate2025-06-04
AnnouncementXMLSubmission_2025-06-03_20:15:55.861.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXinya Gao
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-03-03 23:51:53ID requested
12025-06-03 20:15:56announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: CD37,phagocytosis, cancer cell
Contact List
Jie Li
contact affiliationWomen and Children's Medical Center, Guangzhou Medical University
contact emaillijie2958@gwcmc.org
lab head
Xinya Gao
contact affiliationWomen and Children's Medical Center, Guangzhou Medical University
contact emailsurgeong@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI