PXD061430
PXD061430 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteome of human glioblastoma and meningioma tissue small extracellular vesicles |
| Description | Small extracellular vesicles (EVs) have gained attention in the neurology field due to their role in cell-to-cell communication and their potential diagnostic and therapeutic applications. Despite progress in the field, there remains a gap in our understanding of the composition and function of EVs in brain tumours. Previous studies have primarily evaluated EVs obtained from patient fluids or cell cultures, rather than directly from the tumour tissue. Here we successfully isolated EVs from biopsies of glioblastoma (GBM) or meningioma (MNG) tumors obtained during surgery, marking the first report of in situ EV isolation from brain tumors. The protein content of the tumors and their EVs was characterized using tandem mass spectrometric proteomics, revealing proteins exclusively detected or enriched in EVs relative to tumor. While our study confirmed the presence of proteins previously identified in GBM and MNG EVs from various sources, it also identified novel proteins and pathways associated with EVs from these tumour types. This study underscores the benefit of analyzing in situ EVs direct from brain tissue for insights into tumor biology and highlights the need for further research comparing various types and grades of brain tumors. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-03-04 |
| AnnouncementXML | Submission_2025-03-04_15:18:46.889.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Huaqi Su |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-03-03 23:23:16 | ID requested | |
| ⏵ 1 | 2025-03-04 15:18:47 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: extracellular vesicles, glioblastoma, meningioma, proteomics, exosomes, DatasetType:Proteomics |
Contact List
| Dr. Laura Vella | |
|---|---|
| contact affiliation | The Florey Institute of Neuroscience and Mental Health |
| contact email | laura.vella@unimelb.edu.au |
| lab head | |
| Huaqi Su | |
| contact affiliation | The University of Melbourne |
| contact email | huaqi.su@unimelb.edu.au |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v09/MSV000097225/ |
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