PXD061401

PXD061401 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identification of METTL3 arginine methylation sites in CDDP-resistant Hey cells LC-MS
Description	Previous studies have shown that nuclear localization of METTL3 is associated with CDDP resistance. To identify key PTMS involved in the nuclear localization of METTL3 in CDDP-resistant ovarian cancer cells, we assessed the global methylation of arginine, as well as METTL3 phosphorylation, acetylation, O-GlcNAcylation, and crotonylation in CDDP-resistant and parental ovarian cancer cells. The results showed that arginine methylation of METTL3 was increased in CDDP-resistant cell lines. To further identify the arginine methylation sites that may be involved in the METTL3 resistance mechanism, we identified the methylation modification sites of METTL3 by mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2025-03-06
AnnouncementXML	Submission_2025-03-06_01:39:50.865.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ronghui Zhong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	dimethylated residue
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-03 07:28:05	ID requested
⏵ 1	2025-03-06 01:39:51	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: METTL3 arginine methylation sites

submitter keyword: METTL3 arginine methylation sites

Contact List

Tianzhi huang
contact affiliation	Huang Lab, State Key Laboratory of Cellular Stress Biology, Xiamen University
contact email	huangtianzhi@xmu.edu.cn
lab head
Ronghui Zhong
contact affiliation	State Key Laboratory of Cellular Stress Biology
contact email	zhongronghui0821@163.com
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD061401

PRIDE project URI

Repository Record List

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