PXD061380

PXD061380 is an original dataset announced via ProteomeXchange.

Title	Lactylation of PDP2 Promotes Temozolomide Resistance in Glioblastoma via Activation of Mitochondrial Tricarboxylic Acid Cycle
Description	The aim of this project was to investigate the functional role of protein lactoacylation modification in mitochondrial metabolism. To achieve this, we isolated cellular mitochondria and conducted an immunoprecipitation (IP) assay using a pan-lactoacylation antibody (Pan-Kla) to analyze the lactoacylation proteome within mitochondria. Lactoacylation, a recently identified post-translational modification of proteins, has been shown to play a critical role in cellular metabolism and gene expression regulation. This study will employ mass spectrometry to identify and quantify the IP products, thereby elucidating the specific targets of lactoacylation modification in cancer cells and their biological significance. Our findings may provide novel potential targets for cancer therapy.
HostingRepository	iProX
AnnounceDate	2025-03-03
AnnouncementXML	Submission_2026-03-02_18:00:19.400.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Simin Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	lactic acid
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-02 22:34:48	ID requested
⏵ 1	2026-03-02 18:00:19	announced

Dataset with its publication pending

submitter keyword: PanKla，IP，Lactylation，CellLine，U251

Xiaobing Jiang
contact affiliation	Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
contact email	2004xh0835@hust.edu.cn
lab head
Simin Liu
contact affiliation	Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
contact email	simin2641@163.com
dataset submitter

iProX dataset URI