PXD061360

PXD061360 is an original dataset announced via ProteomeXchange.

Title	Identification of Determinants for Variability in Mitochondrial Biochemical Complex Activities
Description	Diagnosis of mitochondrial disease is based on multiple criteria, such as clinical scores (assessing muscle, central nervous system, and multisystem involvement), imaging results, biopsy histology, genome analyses and biochemical analyses of the electron transport chain complex activities. The complex activities vary strongly between healthy individuals and limits the use for diagnosis. In this project, we have evaluated posttranslational and genetic contributors to such variation in complex activities that -if corrected for- could improve diagnostic precision. We have used proteomic analyses of mitochondria to examine the degree that protein composition of the mitochondria correlates with biochemical activity of complexes as well as posttranslational and genetic factors.
HostingRepository	PRIDE
AnnounceDate	2025-03-06
AnnouncementXML	Submission_2025-03-06_01:55:41.010.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tuula Nyman
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF fleX

Revision	Datetime	Status	ChangeLog Entry
0	2025-03-02 10:50:44	ID requested
⏵ 1	2025-03-06 01:55:41	announced

Dataset with its publication pending

submitter keyword: human muscle mitochondria, mtDNA, DDM, mitochondrial disease, ETC

Tuula Nyman
contact affiliation	Head of Proteomics
contact email	tuula.nyman@medisin.uio.no
lab head
Tuula Nyman
contact affiliation	University of Oslo
contact email	tuula.nyman@medisin.uio.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD061360

PRIDE project URI

• PRIDE
  1. PXD061360
     1. Label: PRIDE project
     2. Name: Identification of Determinants for Variability in Mitochondrial Biochemical Complex Activities