PXD061323

PXD061323 is an original dataset announced via ProteomeXchange.

Title	Human cancer cell proteomics identifies proteins that fail to be degraded upon treatment with a selective autophagy inhibitor
Description	To identify the subproteome degraded by lysosomes in human cancer cells, we compared whole cell proteomes of wild-type and autophagy-deficient non-small cell lung cancer cells in the presence or absence of a lysosomal degradation inhibitor (N/L). Further, we compared whole cell proteomes of cells treated with a selective autophagy inhibitor in the presence or absence of N/L to identify lysosome substrate proteins that fail to be degraded upon treatment with this small molecule.
HostingRepository	PRIDE
AnnounceDate	2025-05-03
AnnouncementXML	Submission_2025-05-03_09:25:33.436.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Simone Sidoli
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-28 14:35:38	ID requested
⏵ 1	2025-05-03 09:25:33	announced

Dataset with its publication pending

submitter keyword: cancer,autophagy, lysosome, degradation, substrate

Simone Sidoli
contact affiliation	Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States
contact email	simone.sidoli@einsteinmed.edu
lab head
Simone Sidoli
contact affiliation	Albert Einstein College of Medicine
contact email	simone.sidoli@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD061323

PRIDE project URI

• PRIDE
  1. PXD061323
     1. Label: PRIDE project
     2. Name: Human cancer cell proteomics identifies proteins that fail to be degraded upon treatment with a selective autophagy inhibitor