⮝ Full datasets listing
PXD061311
PXD061311 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative verification of PLIN2 and PLIN5 peptides in human skeletal muscle via parallel reaction monitoring |
| Description | Energy deficit has shaped human evolution and represents a potent physiological stressor associated with improvements in lifespan and health span in several species. Preserving locomotive capacity has likely been essential for food procurement and survival from starvation during the hunter-gatherer period. However, we have a very limited understanding of the effect of an energy deficit on skeletal muscle, a key tissue for locomotion and metabolic health. Our label-free proteomic analysis discovered that energy deficit shifts skeletal muscle towards an oxidative phenotype as compared to energy balance. This dataset includes targeted proteomic analysis of PLIN2 and PLIN5 peptides using parallel reaction monitoring (PRM) to verify findings from our label-free discovery proteomics data. ClinicalTrials.gov ID: NCT05203133 |
| HostingRepository | PanoramaPublic |
| AnnounceDate | 2025-11-10 |
| AnnouncementXML | Submission_2025-11-10_13:27:18.906.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Yusuke Nishimura |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | Label:13C(5)15N(1); Label:13C(2)15N(1) |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-02-28 08:39:43 | ID requested | |
| ⏵ 1 | 2025-11-10 13:27:19 | announced |
Publication List
| Nishimura Y, Langan-Evans C, Taylor HL, Foo WL, Morton JP, Shepherd S, Strauss JA, Burniston JG, Areta JL, Endocrine, Metabolic, and Skeletal Muscle Proteomic Responses During Energy Deficit With Concomitant Aerobic Exercise in Humans. FASEB J, 39(21):e71163(2025) [pubmed] |
Keyword List
| submitter keyword: PLIN2, PLIN5, PRM, Skeletal muscle, Energy deficit |
Contact List
| Jatin Burniston | |
|---|---|
| contact affiliation | Liverpool John Moores University |
| contact email | j.burniston@ljmu.ac.uk |
| lab head | |
| Yusuke Nishimura | |
| contact affiliation | Liverpool John Moores Univeristy |
| contact email | y.nishimura@ljmu.ac.uk |
| dataset submitter | |
Full Dataset Link List
| Panorama Public dataset URI |
