PXD061285 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity |
Description | Multi-epitope affinity purification mass spectrometry (meAP-MS) analysis of TMEM9-, TMEM9B- and CLC3- associated proteins from solubilized mouse brain membranes identified chloride channel subtypes CLCN3, 4 and 5 as exclusive interaction partners of TMEM9 and TMM9B. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-07_07:48:22.114.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD061285 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Alexander Haupt |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2025-02-27 15:01:39 | ID requested | |
⏵ 1 | 2025-05-07 07:48:22 | announced | |
Publication List
10.6019/PXD061285; |
10.1038/s41467-025-58546-3; |
Planells-Cases R, Vorobeva V, Kar S, Schmitt FW, Schulte U, Schrecker M, Hite RK, Fakler B, Jentsch TJ, -subunits for regulation and prevention of disease-causing overactivity. Nat Commun, 16(1):3117(2025) [pubmed] |
Keyword List
submitter keyword: AP-MS, chloride channels, membrane protein complex, auxiliary subunits,mouse brain, protein-protein interactions |
Contact List
Prof. Dr. Bernd Fakler |
contact affiliation | Institute of Physiology II, Universität Freiburg, Germany |
contact email | bernd.fakler@physiologie.uni-freiburg.de |
lab head | |
Alexander Haupt |
contact affiliation | University of Freiburg, Germany |
contact email | alexander.haupt@physiologie.uni-freiburg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD061285 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061285
- Label: PRIDE project
- Name: Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity