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PXD061285

PXD061285 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEndosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity
DescriptionMulti-epitope affinity purification mass spectrometry (meAP-MS) analysis of TMEM9-, TMEM9B- and CLC3- associated proteins from solubilized mouse brain membranes identified chloride channel subtypes CLCN3, 4 and 5 as exclusive interaction partners of TMEM9 and TMM9B.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-07_07:48:22.114.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD061285
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterAlexander Haupt
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-02-27 15:01:39ID requested
12025-05-07 07:48:22announced
Publication List
10.6019/PXD061285;
10.1038/s41467-025-58546-3;
Planells-Cases R, Vorobeva V, Kar S, Schmitt FW, Schulte U, Schrecker M, Hite RK, Fakler B, Jentsch TJ, -subunits for regulation and prevention of disease-causing overactivity. Nat Commun, 16(1):3117(2025) [pubmed]
Keyword List
submitter keyword: AP-MS, chloride channels, membrane protein complex, auxiliary subunits,mouse brain, protein-protein interactions
Contact List
Prof. Dr. Bernd Fakler
contact affiliationInstitute of Physiology II, Universität Freiburg, Germany
contact emailbernd.fakler@physiologie.uni-freiburg.de
lab head
Alexander Haupt
contact affiliationUniversity of Freiburg, Germany
contact emailalexander.haupt@physiologie.uni-freiburg.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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