PXD061241

PXD061241 is an original dataset announced via ProteomeXchange.

Title	BCG-trained macrophages couple LDLR upregulation to type I IFN responses and anti-viral immunity
Description	Trained immunity refers to memory-like responses of innate immune cells when they re-encounter pathogenic stimuli. Bacillus Calmette-Guérin (BCG) vaccination implies enhanced antiviral immunity whereas the underlying mechanisms remain unclear. Herein, we have uncovered elevated expression of low-density lipoprotein receptor (LDLR) on BCG-trained macrophages with robust type I interferon (IFNI) production and antiviral effects both in vivo and in vitro. Consequently, cholesterol is accumulated in BCG-trained macrophages, leading to the augmentation of NFE2L1 expression and the formation of NFE2L1/IRAK1/TRIM25 complex where TRIM25 mediates IRAK1 K63 polyubiquitination to exaggerate IFNI responses in a RIG-I dependent manner.
HostingRepository	iProX
AnnounceDate	2025-02-27
AnnouncementXML	Submission_2025-02-26_19:58:15.613.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yangdian Lai
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-26 19:58:04	ID requested
⏵ 1	2025-02-26 19:58:16	announced

Dataset with its publication pending

submitter keyword: NFE2L1

Ying Wang
contact affiliation	Shanghai Jiao Tong University School of Medicine
contact email	ywang@sibs.ac.cn
lab head
Yangdian Lai
contact affiliation	Shanghai Jiao Tong University School of Medicine
contact email	laiyangdian@163.com
dataset submitter

iProX dataset URI