PXD061216

PXD061216 is an original dataset announced via ProteomeXchange.

Title	Exploration of the visual streak of the Mongolian gerbil as a model for the human central retina
Description	The Mongolian gerbil (MG), a day-active rodent, features a particular retinal region of high visual acuity, the visual streak (VS). Optimized for vision in desert-like environments, the VS allows for a particularly good view of the horizon between the projection areas of the sky and the ground. Here, we assess the structural basis of this specialized region and compare the findings to the conditions at the human retinal center. The VSs of MG retinas (n=5) were evaluated morphologically with immunohistochemistry for cone, rod, and RPE cell-specific markers in dorsoventral cross-sections, and the results were compared to data from the near (adjacent) and far periphery. Mass spectrometry of the VS and peripheral retina/RPE was used for analysis of the proteomic differential expression between these regions. In the VS of the MG, we found an increased density of cones, elongated photoreceptor outer segments (OSs), and a rod-to-cone ratio lying within the zone of descent between the border of the macula and the fovea (macular shoulder). Likewise, the base area of retinal pigment epithelium (RPE) cells in the VS was significantly reduced, while cells were taller than those in the periphery. Accordingly, proteomic data provided evidence for an enhanced abundance of key proteins relevant for photoreceptor and RPE function and pathophysiology of macular diseases in the VS. The high degree of conformance between the VS data of the MG and the human central retina renders the MG a promising rodent, non-primate model of the central human retina
HostingRepository	MassIVE
AnnounceDate	2025-02-26
AnnouncementXML	Submission_2025-02-26_02:14:04.199.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mohamed Ali Jarboui
SpeciesList	scientific name: Meriones unguiculatus; common name: Mongolian gerbil; NCBI TaxID: 10047;
ModificationList	Oxidation; Deamidated; Carbamidomethyl
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-26 01:59:56	ID requested
⏵ 1	2025-02-26 02:14:04	announced

Alexander Günter * , Mohamed Ali Jarboui , Regine Lotte Muehlfriedel and Mathias W Seeliger. Exploration of the visual streak of the Mongolian gerbil as a model for the human central retina. Front. Med. February 2025 (Submitted).

submitter keyword: DIA, LFQ, GErbil, Eye, Retina, DatasetType:Proteomics

Mohamed Ali Jarboui
contact affiliation	core facility medical proteomics, University klinikum Tuebingen
contact email	mohamed-ali.jarboui@uni-tuebingen.de
lab head
Mohamed Ali Jarboui
contact affiliation	University klinikum Tuebingen
contact email	mohamed-ali.jarboui@uni-tuebingen.de
dataset submitter

MassIVE dataset URI

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