PXD061152 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Age-Linked Variations in Adipose Tissue Responses to Nerve Injury in a murine model: Sex-Specific Patterns Over Time |
| Description | Adipose tissue (AT) plays a central role in the metabolic and inflammatory responses to neuropathy. It secretes adipokines, such as leptin and adiponectin, which regulate nerve regeneration and inflammation . Postmenopausal women have a higher prevalence of PN, linked to estrogen depletion, which influences immune and inflammatory pathways. Estrogens promote Schwann cell (SC) activity and reduce oxidative stress, offering neuroprotective benefits . Our proteomic analysis is part of the comprehensive investigation in a mouse model of peripheral nerve injury, utilizing behavioral, imaging, biochemical, molecular, and -omics approaches. Our objective is to elucidate the sex-specific metabolic roles of AT in aging-related neuropathy and pain. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-10 |
| AnnouncementXML | Submission_2025-11-09_18:01:56.607.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD061152 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Luisa Pieroni |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Synapt MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-02-24 17:27:03 | ID requested | |
| ⏵ 1 | 2025-11-09 18:01:57 | announced | |
Publication List
| 10.3389/fpain.2025.1655712; |
| Marinelli S, Rossi C, Pieroni L, Giacovazzo G, Vacca V, De Angelis F, Cicalini I, Mastrorilli V, Parisi C, Yurtsever ZN, Ciavardelli D, Coccurello R, Metabolic resilience governs sex-specific pain recovery during hormonal aging: a multi-omics study of neuropathy in mice. Front Pain Res (Lausanne), 6():1655712(2025) [pubmed] |
| 10.6019/PXD061152; |
Keyword List
| submitter keyword: Gender,Mouse, LC-MS |
Contact List
| Luisa Pieroni |
|---|
| contact affiliation | Unicamillus, International Medical University of Rome, Departmental Faculty of Medicine and Surgery |
| contact email | luisa.pieroni@unicamillus.org |
| lab head | |
| Luisa Pieroni |
|---|
| contact affiliation | Unicamillus, International Medical University of Rome, Departmental Faculty of Medicine and Surgery,Via di Sant’Alessandro, 8, 00131 Rome – IT |
| contact email | luisa.pieroni@unicamillus.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD061152 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061152
- Label: PRIDE project
- Name: Age-Linked Variations in Adipose Tissue Responses to Nerve Injury in a murine model: Sex-Specific Patterns Over Time
