PXD061144

PXD061144 is an original dataset announced via ProteomeXchange.

Title	In-depth plasma proteomics of patients with suspected lung cancer (lung adenocarcinoma and non-cancer controls) with HiRIEF LC-MS/MS
Description	Here, we present an in-depth proteomic profiling of pre-diagnostic plasma samples from 114 individuals with suspected lung cancer, including 57 patients diagnosed with stage III-IV lung adenocarcinoma (LUAD) and 57 non-cancer controls. Plasma samples were depleted of high-abundant proteins, and proteomic analysis was performed using high-resolution isoelectric focusing (HiRIEF) coupled with liquid chromatography tandem mass spectrometry (LC-MS/MS), with relative quantification by isobaric tandem mass tags (TMT16-plex).
HostingRepository	PRIDE
AnnounceDate	2025-11-11
AnnouncementXML	Submission_2025-11-11_12:30:59.211.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Noora Sissala
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-24 11:21:52	ID requested
⏵ 1	2025-11-11 12:31:00	announced

10.1038/s42004-025-01753-2;

Sissala N, Baba, č, i, ć H, Leo IR, Cao X, Forshed J, Eriksson LE, Lehti, ö J, Fredolini C, Å, berg M, Pernemalm M, Comparative evaluation of Olink Explore 3072 and mass spectrometry with peptide fractionation for plasma proteomics. Commun Chem, 8(1):327(2025) [pubmed]

submitter keyword: None

Janne Lehtiö
contact affiliation	Department of Oncology-Pathology, Karolinska Institutet
contact email	janne.lehtio@ki.se
lab head
Noora Sissala
contact affiliation	Karolinska Institutet
contact email	noora.sissala@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD061144

PRIDE project URI

• PRIDE
  1. PXD061144
     1. Label: PRIDE project
     2. Name: In-depth plasma proteomics of patients with suspected lung cancer (lung adenocarcinoma and non-cancer controls) with HiRIEF LC-MS/MS