PXD061132 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Establishment of global HSC proteomics using LC-MS/MS analysis with the Orbitrap Astral mass spectrometer |
| Description | Epigenetic regulation exerts a crucial role in maintaining the balance between self-renewal and differentiation of hematopoietic stem cells (HSCs), thereby sustaining normal hematopoiesis. Although emerging evidence has demonstrated the contribution of RNA N4-acetylcytidine (ac4C) modification and its catalytic enzyme Nat10 to numerous biological processes, particularly tumorigenesis, the function of Nat10 in normal hematopoiesis remain unexplored. In this study, we characterize the function of Nat10 in hematopoietic stem and progenitor cells (HSPCs) using low input proteomics and reveal a key role of Nat10 in the maintenance of HSCs. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-02 |
| AnnouncementXML | Submission_2025-12-01_18:51:21.236.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Feng Huang |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-02-24 05:34:34 | ID requested | |
| ⏵ 1 | 2025-12-01 18:51:21 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ac4C, proteomics,Nat10, translation |
Contact List
| Feng huang |
|---|
| contact affiliation | Guangzhou National Laboratory, Guangzhou 510005, China |
| contact email | huang_feng@gzlab.ac.cn |
| lab head | |
| Feng Huang |
|---|
| contact affiliation | Guangzhou Lab |
| contact email | huang_feng@gzlab.ac.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD061132 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD061132
- Label: PRIDE project
- Name: Establishment of global HSC proteomics using LC-MS/MS analysis with the Orbitrap Astral mass spectrometer
