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PXD061112

PXD061112 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identifying target proteins of capsazepine using DARTS technology
Description	This study employs DARTS (Drug Affinity Responsive Target Stability) to investigate capsazepine's targets. The technique detects drug-induced proteolytic resistance in target proteins, coupled with mass spectrometry to capture drug-protein complexes. Experiments focus on identifying novel targets beyond TRPV1 (e.g., G protein-coupled receptors) to elucidate its analgesic mechanisms and polypharmacological effects. Key findings may advance pharmacological optimization of analgesics and expand therapeutic applications.
HostingRepository	iProX
AnnounceDate	2025-02-23
AnnouncementXML	Submission_2025-02-23_19:15:48.208.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuzhang Yang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-23 19:14:32	ID requested
⏵ 1	2025-02-23 19:15:48	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: DARTS

Contact List

Yuzhang Yang
contact affiliation	Shanghai University of Traditional Chinese Medicine
contact email	1430933190@qq.com
lab head
Yuzhang Yang
contact affiliation	Shanghai University of Traditional Chinese Medicine
contact email	1430933190@qq.com
dataset submitter

Full Dataset Link List

iProX dataset URI