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PXD061079

PXD061079 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAnti-Cancer potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the centrosome
DescriptionAnaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma affecting children and young adults. About 30% of patients develop therapy resistance therefore new precision medicine drugs are highly warranted. Multiple rounds of structure-activity optimization of Caffeic Acid Phenethyl Ester have resulted in CM14. CM14 causes upregulation of genes involved in oxidative stress response and downregulation of DNA replication genes leading to G2/M arrest and subsequent apoptosis induction. In accordance with this, an unbiased proteomics approach, confocal microscopy and molecular modeling showed that TUBGCP2, member of the centrosomal γ-TuRC complex, is a direct interaction partner of CM14. CM14 overcomes ALK inhibitor resistance in ALCL and is also active in T-cell Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia. Interestingly, CM14 also induced cell death in docetaxel-resistant prostate cancer cells thus suggesting an unexpected role in solid cancers. Thus, we synthesized and thoroughly characterized a novel TUBGCP2 targeting drug that is active in ALCL but has also potential for other malignancies.
HostingRepositoryPRIDE
AnnounceDate2025-03-06
AnnouncementXMLSubmission_2025-03-06_08:50:48.170.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKaterina Hanakova
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-02-22 09:45:13ID requested
12025-03-06 08:50:48announced
Publication List
10.1016/J.REDOX.2025.103582;
Keyword List
submitter keyword: ALCL, CM14, LC-MS/MS
Contact List
Zbynek Zdrahal
contact affiliationProteomics Core Facility and Research Group Proteomics, CEITEC-MU, Masaryk University, Brno, Czech Republic
contact emailzdrahal@sci.muni.cz
lab head
Katerina Hanakova
contact affiliationCEITEC MU
contact emailkaterina.hanak@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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